Cancer Chemotherapy and Antioxidants

Free Radicals: The Pros and Cons of Antioxidants Cancer Chemotherapy and Antioxidants

Does the administration of antioxidants during cancer chemotherapy affect antineoplastic efficacy or the development of side effects? Although the majority of preclinical studies involving the use of in vitro systems and animal models support the contention that certain antioxidants are of benefit, few clinical studies have been done (1,2). Factors to consider in the design of studies to answer...

Mathematical Modeling and Lyapunov-Based Drug Administration in Cancer Chemotherapy

In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a...

The Use of Antioxidants with Chemotherapy and Radiotherapy in Cancer Treatment: A Review

Glutathione Glutathione/colorectal cancer: Neuroprotective effect of glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: A randomized double-blind, placebocontrolled trial Fifty-two patients with advanced colorectal cancer were randomized to receive glutathione (1,500 mg/m2 over a 15 minute infusion period before oxaliplatin) or normal saline solution. At baseline, no p...

Prostate Cancer, Inflammation and Antioxidants

Dietary antioxidants and human cancer.

Epidemiological studies show that a high intake of anti-oxidant-rich foods is inversely related to cancer risk. While animal and cell cultures confirm the anticancer effects of antioxidants, intervention trials to determine their ability to reduce cancer risk have been inconclusive, although selenium and vitamin E reduced the risk of some forms of cancer, including prostate and colon cancer, an...